Nuria Flames

• 2000 Licensed Biology, Universidad de Valencia
• 2005 PhD in Neuroscience, Universidad Miguel Hernández

• 2001-2006 PhD student, Dr Oscar Marín laboratory, Instituto Neurociencias de Alicante
• 2006-2011 Postdoctoral researcher, Dr Oliver Hobert, HHMI, Columbia University, New York
• 2011-14 Ramón y Cajal, Instituto Biomedicina de Valencia
• 2014-2023 Científico titular, Instituto Biomedicina de Valencia
• 2022 (6 month stay) Research visiting fellow, King’s College London

2026: Asia-Pacific Worm meeting.
2025: 11th European Conference of Comparative Neurobiology. Alicante.
2025: Novelty, co-option and divergence during gene network evolution. Company of Biologist Workshop. West Sussex, UK
2024: European Worm Meeting. Utrech.
2023: 45th British Society for Cell Biology (BSCB) GenSoc UK Cilia Network e-symposium.
2022: Plenary lecture, VIII Spanish Worm Meeting, Logroño.
2021: Jornadas Instituto de Neurociencias UAB, Sant Feliu de Guixols.
2019: Red Neurogenesis Adulta (RENA), Valencia
2018: 41º SEBBM meeting, Santander
2017: First Latin American Worm Meeting, Montevideo
2016: XI SEBD Meeting, Girona.
2012: US EMBO fellows meeting (New York).

(From last ten years, full list of publications below)

• Poole RJ*, Flames N*, Cochella L*. Neurogenesis in Caenorhabditis elegans. Genetics. 2024 Aug 21:iyae116. doi: 10.1093/genetics/iyae116. *Co-corresponding authors. Wormbook Chapter
• Brocal-Ruiz R, Esteve-Serrano A, Mora-Martínez C, Franco-Rivadeneira ML, Swoboda P, Tena JJ, Vilar M, Flames N*. Forkhead transcription factor FKH-8 cooperates with RFX in the direct regulation of sensory cilia in Caenorhabditis elegans. 2023 Jul 14;12:e89702. doi: 10.7554/eLife.89702. Traditional eLife ACCEPTED/REJECTED track.
• Aydin B, Sierk M, Moreno-Estelles M, Tejavibulya L, Kumar N, Flames N*, Mahony S*, Mazzoni EO*. Foxa2 and Pet1 Direct and Indirect Synergy Drive Serotonergic Neuronal Differentiation. Front Neurosci. 2022 Jun 20;16:903881. doi: 10.3389/fnins.2022.903881. *Co-corresponding authors.
• Sousa E, Flames N*. Transcriptional regulation of neuronal identity. Eur J Neurosci. 2022. Feb;55(3):645-660. doi: 10.1111/ejn.15551. Epub 2022 Jan 18. Invited Review. Jimeno-Martín A, Sousa E, Daroqui N, Brocal-Ruiz R, Maicas M, Flames N*. Transcription factors from multiple families ensure enhancer selectivity and robust neuron terminal differentiation. Genome Res. 2022 Mar;32(3):459-473. doi: 10.1101/gr.275623.121. Epub 2022 Jan 24.
• Miren M., Jimeno-Martín A., Millán-Trejo A., Alkema and Flames N*. Notch independent functions of LAG-1/CSL control terminal differentiation, maintenance and gene expression plasticity of a chemosensory neuron. PLOS Biology, 2021 Jul 7;19(7):e3001334.
• Remesal L., Roger-Banyat I., Chirivella L., Maicas M., Brocal-Ruiz R., Pérez-Villalva A., Cucarella C., Casado M., Flames N*. PBX1 is a terminal selector of olfactory bulb dopaminergic neurons. 2020 Apr 13;147(8):dev186841. doi: 10.1242/dev.186841.
• Aydin B., Kakumanu A., Rossillo M., Moreno-Estellés M., Garipler G., Ringstad N., Flames N., Mahony S. and MazzoniE.O. Proneural factors Ascl1 and Neurog2 contribute to neuronal subtype identities by establishing distinct chromatin landscapes. Nature Neuroscience. 2019 Jun;22(6):897-908.
• Lloret-Fernandez C, Maicas M, Mora-Martinez C, Artacho A, Jimeno-Martín Á, Weinberg P, Flames N*. A transcription factor collective defines the HSN serotonergic neuron regulatory landscape. eLife. 2018.

Zhang F., Bhattacharya1 A., Nelson J.C., Abe N., Gordon P.,
 Lloret-Fernandez C., Maicas M., Flames N., Mann R.S, Colón-Ramos D.A and Hobert O. The LIM and POU homeobox genes ttx-3 and unc-86 act as terminal selectors in distinct cholinergic and serotonergic neuron types. Development, 2014. 141, 422-435.

• Transcriptional regulatory programs controlling neuron morphology and neuronal resilience. Generalitat Valenciana CIAICO/2022/195
• Especificación, evolución y plasticidad de tipos neuronales con importancia biomédica. Plan Nacional PID2020-115635RB-I00
• Regulatory rules and evolution of neuronal gene expression. NEUROCODE. ERC Consolidator Grant
• Programas de regulación transcripcional asociados a enfermedades genéticas. Agency: MINECO, SAF2017-84790-R.
• Estudio de los mecanismos transcripcionales que regulan la diferenciación de las neuronas monoaminérgicas y su conservación evolutiva. Agency: MINECO, SAF2014-56877-R
• Dissecting the gene regulatory mechanisms that generate serotonergic neurons and their link to mental disorders. ERC Starting Grant.
• Dissecting the gene regulatory mechanisms that generate serotonergic neurons. Marie Curie Actions. Career Integration Grants.

• Quart es ciència. Semana del cerebro. Enero 2024.
• TEDX talk UV, crisis es momento de crecer, 2021.
• Mesa redonda Mujer y Niña en la Ciencia Instituto Cervantes Bruselas/CSIC. Febrero 2020.
• Jornada Dones Neurocientífiques, Universidad de Valencia. Febrero 2018.
• Las científicas cuentan, Divulgación Mujer y Ciencia CSIC. 2018

• 2010 Michael J. Fox Foundation. Rapid Response Innovation Award
• 2010 NARSAD Young Investigator Award.
• 2010 Mención de honor Premio Joven Investigador Universidad Complutense de Madrid.

• Organizing committee Spanish Worm Meeting Valencia, 2026.
• Organizing committee elegans neuro-meeting, Bourdeaux, 2026
• Executive committee Conexión Genoma. 2023-2025.
• Head of the Caenorhabiditis Genetics Center (CGC) European hub for strain distribution.
• Scientific advisory board ITN NervSpan 2024-2027.
• «Embajadora» conexión Biología Computacional y Bioinformática CSIC.
• Panel member for National Research Agency: Plan Nacional BMC 2025; RyC 2024 BIO; Plan Nacional BME-ESN 2019; JdC 2012.
• Reviewer for funding agencies (ERC, HFSP, ANR, AEI, Junta Andalucía)
• Organizing committee Spanish Worm Meeting Valencia 2017
• Organizing committee SEBBM, Valencia 2015
• Scientific supervisor Microscopy facility IBV. Since 2015
• Reviewer for journals (Science, Nature, Science Advances, eLife, PNAS, Human Molecular Genetics, Cell Reports., Nat. Com., Development, etc.)
• Chair of a symposium, FENS meeting (European Neuroscience Meeting) 2014: Regulatory mechanisms of neuronal specification

• 31/10/2011 to 15/03/2012 Maternity leave (4.5 months).
• 22/07/2013 to 15/03/2012 Maternity leave (4.5 months).