Unit
BIOMOLECULAR NMR
Description
We study the molecular recognition of biomolecules relevant to human health, using nuclear magnetic resonance (NMR) and other complementary techniques. We focus on proteins involved in DNA replication and repair (Proliferating Cell Nuclear Antigen), chromatin remodeling (INhibitors of Growth) and cell signaling (G proteins), which interact with diverse ligands to carry out their function in healthy cells, but cause cancer and other diseases when dysregulated. Understanding the molecular basis of their interactions may help developing therapeutic strategies.
Model of an ensemble with 10 different p15 protein conformers bound to the PCNA ring (grey surface) illustrating the disordered state of the p15 tails and the ordered central region, as seen by NMR, crystallography, and computational calculations.