Unit
ONCOGENIC SIGNALLING
Description
Cancer cells hijack fundamental molecular processes to drive uncontrolled growth, evade treatment, and spread throughout the body. Our lab is dedicated to uncovering how these processes, particularly those controlling cell proliferation, proteostasis, and stress adaptation, are reprogrammed in tumours. By integrating molecular biology with patient-derived models, we identify new therapeutic vulnerabilities and biomarkers to guide more effective, personalised cancer therapies.
Key Research Areas
1. Growth and Invasion Programs in Cancer
We investigate how oncogenic signals rewire transcriptional networks to drive abnormal proliferation and invasive traits in solid tumours.
2. Translational Control and Cancer Cell Adaptation
We explore how dysregulated protein synthesis and selective mRNA translation contribute to therapy resistance and stress survival.
3. Tumour Heterogeneity and Resistance Mechanisms
Using patient-derived models, we dissect how diverse cancer cell populations evolve, metastasise, and evade treatment.
Our Approach
We hypothesise that core molecular regulators of cell growth and division also orchestrate cancer cell plasticity, enabling tumours to adapt under therapeutic pressure. By decoding these mechanisms, we aim to develop novel strategies to disrupt cancer progression and improve patient outcomes.
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